Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein

Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein

α-synuclein (αSyn) is the main protein component of Lewy bodies, intracellular inclusions found in the brain of Parkinson’s disease (PD) patients. Neurotoxic αSyn species are broadly modified post-translationally and, in patients with genetic forms of PD, carry genetically encoded amino acid substit...

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Bibliographic Details
Main Authors: Ana Martinez Hernandez, Ivan Silbern, Insa Geffers, Lars Tatenhorst, Stefan Becker, Henning Urlaub, Markus Zweckstetter, Christian Griesinger, Gregor Eichele
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neuroscience
Subjects:
α-Synuclein
Parkinson’s disease
transgenic mouse
truncation
oligomerization
motor impairment
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.643391/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.643391/full

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