Trehalose Modulates Autophagy Process to Counteract Gliadin Cytotoxicity in an In Vitro Celiac Disease Model

Trehalose Modulates Autophagy Process to Counteract Gliadin Cytotoxicity in an In Vitro Celiac Disease Model

Celiac disease (CD) is a chronic systemic autoimmune disorder that is triggered by the ingestion of gliadin peptides, the alcohol-soluble fraction of wheat gluten. These peptides, which play a key role in the immune response that underlies CD, spontaneously form aggregates and exert a direct toxic a...

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Bibliographic Details
Main Authors: Federico Manai, Alberto Azzalin, Martina Morandi, Veronica Riccardi, Lisa Zanoletti, Marco Dei Giudici, Fabio Gabriele, Carolina Martinelli, Mauro Bozzola, Sergio Comincini
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cells
Subjects:
celiac disease
gluten
gliadin
autophagy
Caco-2 cells
trehalose
Online Access:https://www.mdpi.com/2073-4409/8/4/348

Internet

https://www.mdpi.com/2073-4409/8/4/348

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