Cryo-EM structure of a transthyretin-derived amyloid fibril from a patient with hereditary ATTR amyloidosis

Cryo-EM structure of a transthyretin-derived amyloid fibril from a patient with hereditary ATTR amyloidosis

Systemic amyloidosis of the ATTR is one of the most abundant forms of systemic amyloidosis and caused by misfolding of the circulating blood protein transthyretin (TTR). Here the authors present the cryo-EM structure of patient-derived Val30Met ATTR amyloid fibrils which reveals that the protofilame...

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Bibliographic Details
Main Authors: Matthias Schmidt, Sebastian Wiese, Volkan Adak, Jonas Engler, Shubhangi Agarwal, Günter Fritz, Per Westermark, Martin Zacharias, Marcus Fändrich
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13038-z

Internet

https://doi.org/10.1038/s41467-019-13038-z

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