Importance of Cullin4 Ubiquitin Ligase in Malignant Pleural Mesothelioma

Importance of Cullin4 Ubiquitin Ligase in Malignant Pleural Mesothelioma

Neurofibromatosis type 2 (NF2), the tumor suppressor frequently lost in malignant pleural mesothelioma (MPM), suppresses tumorigenesis in part by inhibiting the Cullin4 ubiquitin ligase (CUL4) complex in the nucleus. Here, we evaluated the importance of CUL4 in MPM progression and tested the efficac...

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Bibliographic Details
Main Authors: Mayura Meerang, Jessica Kreienbühl, Vanessa Orlowski, Seraina L. C. Müller, Michaela B. Kirschner, Isabelle Opitz
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
malignant pleural mesothelioma
NF2
ubiquitination
CUL4A
CUL4B
neddylation
Online Access:https://www.mdpi.com/2072-6694/12/11/3460

Internet

https://www.mdpi.com/2072-6694/12/11/3460

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