Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide

Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide

Macropinocytosis is a clathrin-independent endocytosis of extracellular fluid that may contribute to cancer aggressiveness through nutrient supply, recycling of plasma membrane and receptors, and exosome internalization. Macropinocytosis may be notably triggered by epidermal growth factor receptor (...

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Bibliographic Details
Main Authors: Margaux Colin, Cédric Delporte, Rekin’s Janky, Anne-Sophie Lechon, Gwendoline Renard, Pierre Van Antwerpen, William A. Maltese, Véronique Mathieu
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
glioma
macropinocytosis
methuosis
honokiol
vacquinol-1
MOMIPP
temozolomide
Online Access:https://www.mdpi.com/2072-6694/11/3/411

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https://www.mdpi.com/2072-6694/11/3/411

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