Leveraging the Cell Ontology to classify unseen cell types

Classifying cells into unseen cell types remains challenging in scRNA-seq analysis. Here we show that Cell Ontology enables an accurate classification of unseen cell types through considering the cell type relationships in the Cell Ontology graph.

Bibliographic Details
Main Authors: Sheng Wang, Angela Oliveira Pisco, Aaron McGeever, Maria Brbic, Marinka Zitnik, Spyros Darmanis, Jure Leskovec, Jim Karkanias, Russ B. Altman
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25725-x