Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas

Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas

Abstract Background Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic properties, has been implicated in GBM growth. We hypothesized that Sema3A dir...

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Bibliographic Details
Main Authors: Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer, John R. Henley
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Cancer
Subjects:
Semaphorin
Neuropilin
Plexin
Glioma
Brain tumor stem cells
Online Access:https://doi.org/10.1186/s12885-020-07694-4

Internet

https://doi.org/10.1186/s12885-020-07694-4

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