Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice

Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice

We have investigated synaptic function in the hippocampus in mice of different ages carrying a null mutation in the PrP gene. Experiments carried out in vivo and in vitro in two laboratories revealed no differences in the ability of juvenile and young adult control and PrP-null mice to express long-...

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Main Authors: John Curtis, Mick Errington, Tim Bliss, Karen Voss, Nikki MacLeod
Format: Article
Language:English
Published: Elsevier 2003-06-01
Series:Neurobiology of Disease
Subjects:
Prion protein
Transgenic mice
LTP
PTP
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103000172
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spelling doaj-1d0ed513b2ad4f459b2f01e0863475cf2021-03-20T04:48:21ZengElsevierNeurobiology of Disease1095-953X2003-06-011315562Age-dependent loss of PTP and LTP in the hippocampus of PrP-null miceJohn Curtis0Mick Errington1Tim Bliss2Karen Voss3Nikki MacLeod4Biomedical Sciences, University Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UKBiomedical Sciences, University Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UKBiomedical Sciences, University Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UKBiomedical Sciences, University Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UKBiomedical Sciences, University Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UKWe have investigated synaptic function in the hippocampus in mice of different ages carrying a null mutation in the PrP gene. Experiments carried out in vivo and in vitro in two laboratories revealed no differences in the ability of juvenile and young adult control and PrP-null mice to express long-term potentiation, paired-pulse facilitation, or posttetanic potentiation in either the dentate gyrus or in the CA1 region. However, we found a significant reduction in the level of posttetanic potentiation and long-term potentiation in the CA1 region of aged PrP-null mice. These results are discussed in relationship to reported increased levels of oxidative stress in older PrP-null mice.http://www.sciencedirect.com/science/article/pii/S0969996103000172Prion proteinTransgenic miceLTPPTP
collection DOAJ
language English
format Article
sources DOAJ
author John Curtis
Mick Errington
Tim Bliss
Karen Voss
Nikki MacLeod
spellingShingle John Curtis
Mick Errington
Tim Bliss
Karen Voss
Nikki MacLeod
Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice
Neurobiology of Disease
Prion protein
Transgenic mice
LTP
PTP
author_facet John Curtis
Mick Errington
Tim Bliss
Karen Voss
Nikki MacLeod
author_sort John Curtis
title Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice
title_short Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice
title_full Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice
title_fullStr Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice
title_full_unstemmed Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice
title_sort age-dependent loss of ptp and ltp in the hippocampus of prp-null mice
publisher Elsevier
series Neurobiology of Disease
issn 1095-953X
publishDate 2003-06-01
description We have investigated synaptic function in the hippocampus in mice of different ages carrying a null mutation in the PrP gene. Experiments carried out in vivo and in vitro in two laboratories revealed no differences in the ability of juvenile and young adult control and PrP-null mice to express long-term potentiation, paired-pulse facilitation, or posttetanic potentiation in either the dentate gyrus or in the CA1 region. However, we found a significant reduction in the level of posttetanic potentiation and long-term potentiation in the CA1 region of aged PrP-null mice. These results are discussed in relationship to reported increased levels of oxidative stress in older PrP-null mice.
topic Prion protein
Transgenic mice
LTP
PTP
url http://www.sciencedirect.com/science/article/pii/S0969996103000172
work_keys_str_mv AT johncurtis agedependentlossofptpandltpinthehippocampusofprpnullmice
AT mickerrington agedependentlossofptpandltpinthehippocampusofprpnullmice
AT timbliss agedependentlossofptpandltpinthehippocampusofprpnullmice
AT karenvoss agedependentlossofptpandltpinthehippocampusofprpnullmice
AT nikkimacleod agedependentlossofptpandltpinthehippocampusofprpnullmice
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