Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice
We have investigated synaptic function in the hippocampus in mice of different ages carrying a null mutation in the PrP gene. Experiments carried out in vivo and in vitro in two laboratories revealed no differences in the ability of juvenile and young adult control and PrP-null mice to express long-...
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doaj-1d0ed513b2ad4f459b2f01e0863475cf2021-03-20T04:48:21ZengElsevierNeurobiology of Disease1095-953X2003-06-011315562Age-dependent loss of PTP and LTP in the hippocampus of PrP-null miceJohn Curtis0Mick Errington1Tim Bliss2Karen Voss3Nikki MacLeod4Biomedical Sciences, University Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UKBiomedical Sciences, University Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UKBiomedical Sciences, University Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UKBiomedical Sciences, University Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UKBiomedical Sciences, University Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UKWe have investigated synaptic function in the hippocampus in mice of different ages carrying a null mutation in the PrP gene. Experiments carried out in vivo and in vitro in two laboratories revealed no differences in the ability of juvenile and young adult control and PrP-null mice to express long-term potentiation, paired-pulse facilitation, or posttetanic potentiation in either the dentate gyrus or in the CA1 region. However, we found a significant reduction in the level of posttetanic potentiation and long-term potentiation in the CA1 region of aged PrP-null mice. These results are discussed in relationship to reported increased levels of oxidative stress in older PrP-null mice.http://www.sciencedirect.com/science/article/pii/S0969996103000172Prion proteinTransgenic miceLTPPTP |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
John Curtis Mick Errington Tim Bliss Karen Voss Nikki MacLeod |
spellingShingle |
John Curtis Mick Errington Tim Bliss Karen Voss Nikki MacLeod Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice Neurobiology of Disease Prion protein Transgenic mice LTP PTP |
author_facet |
John Curtis Mick Errington Tim Bliss Karen Voss Nikki MacLeod |
author_sort |
John Curtis |
title |
Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice |
title_short |
Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice |
title_full |
Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice |
title_fullStr |
Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice |
title_full_unstemmed |
Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice |
title_sort |
age-dependent loss of ptp and ltp in the hippocampus of prp-null mice |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2003-06-01 |
description |
We have investigated synaptic function in the hippocampus in mice of different ages carrying a null mutation in the PrP gene. Experiments carried out in vivo and in vitro in two laboratories revealed no differences in the ability of juvenile and young adult control and PrP-null mice to express long-term potentiation, paired-pulse facilitation, or posttetanic potentiation in either the dentate gyrus or in the CA1 region. However, we found a significant reduction in the level of posttetanic potentiation and long-term potentiation in the CA1 region of aged PrP-null mice. These results are discussed in relationship to reported increased levels of oxidative stress in older PrP-null mice. |
topic |
Prion protein Transgenic mice LTP PTP |
url |
http://www.sciencedirect.com/science/article/pii/S0969996103000172 |
work_keys_str_mv |
AT johncurtis agedependentlossofptpandltpinthehippocampusofprpnullmice AT mickerrington agedependentlossofptpandltpinthehippocampusofprpnullmice AT timbliss agedependentlossofptpandltpinthehippocampusofprpnullmice AT karenvoss agedependentlossofptpandltpinthehippocampusofprpnullmice AT nikkimacleod agedependentlossofptpandltpinthehippocampusofprpnullmice |
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