Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders

Two novel mouse models mimicking minor deletions in 22q11.2 deletion syndrome revealed the contribution of each deleted region to psychiatric disorders

Abstract 22q11.2 deletion syndrome (22q11.2DS) is a disorder caused by the segmental deletion of human chromosome 22. This chromosomal deletion is known as high genetic risk factors for various psychiatric disorders. The different deletion types are identified in 22q11.2DS patients, including the mo...

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Bibliographic Details
Main Authors: Ryo Saito, Chika Miyoshi, Michinori Koebis, Itaru Kushima, Kazuki Nakao, Daisuke Mori, Norio Ozaki, Hiromasa Funato, Masashi Yanagisawa, Atsu Aiba
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Molecular Brain
Subjects:
22q11.2 deletion syndrome
Mouse models
Rare deletion types
Behavioral analysis
Sleep analysis
Online Access:https://doi.org/10.1186/s13041-021-00778-7

Internet

https://doi.org/10.1186/s13041-021-00778-7

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