Cyclophilin A Promotes Inflammation in Acute Kidney Injury but Not in Renal Fibrosis

Cyclophilin A (CypA) is a highly abundant protein in the cytoplasm of most mammalian cells. Beyond its homeostatic role in protein folding, CypA is a Damage-Associated Molecular Pattern which can promote inflammation during tissue injury. However, the role of CypA in kidney disease is largely unknow...

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Bibliographic Details
Main Authors: Khai Gene Leong, Elyce Ozols, John Kanellis, David J. Nikolic-Paterson, Frank Y. Ma
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/10/3667