Apolipoprotein composition and particle size affect HDL degradation by chymase: effect on cellular cholesterol efflux

Apolipoprotein composition and particle size affect HDL degradation by chymase: effect on cellular cholesterol efflux

Mast cell chymase, a chymotrypsin-like neutral protease, can proteolyze HDL3. Here we studied the ability of rat and human chymase to proteolyze discoidal preβ-migrating reconstituted HDL particles (rHDLs) containing either apolipoprotein A-I (apoA-I) or apoA-II. Both chymases cleaved apoA-I in rHDL...

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Bibliographic Details
Main Authors: Miriam Lee, Petri T. Kovanen, Gabriella Tedeschi, Emanuela Oungre, Guido Franceschini, Laura Calabresi
Format: Article
Language:English
Published: Elsevier 2003-03-01
Series:Journal of Lipid Research
Subjects:
apoA-I proteolysis
mast cell chymase
reconstituted HDL
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520311937

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http://www.sciencedirect.com/science/article/pii/S0022227520311937

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