A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease
Introduction: Blood C-reactive protein (CRP) and fecal calprotectin levels are routinely measured as surrogate markers of disease activity in Inflammatory Bowel Disease (IBD), but often do not correlate well with the degree of mucosal inflammation in the intestine as established by endoscopy. Theref...
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| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2019.00251/full |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Arno R. Bourgonje Julius Z. H. von Martels Ruben Y. Gabriëls Tjasso Blokzijl Manon Buist-Homan Janette Heegsma Bernadien H. Jansen Hendrik M. van Dullemen Eleonora A. M. Festen Rinze W. F. ter Steege Marijn C. Visschedijk Rinse K. Weersma Paul de Vos Klaas Nico Faber Klaas Nico Faber Gerard Dijkstra |
| spellingShingle |
Arno R. Bourgonje Julius Z. H. von Martels Ruben Y. Gabriëls Tjasso Blokzijl Manon Buist-Homan Janette Heegsma Bernadien H. Jansen Hendrik M. van Dullemen Eleonora A. M. Festen Rinze W. F. ter Steege Marijn C. Visschedijk Rinse K. Weersma Paul de Vos Klaas Nico Faber Klaas Nico Faber Gerard Dijkstra A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease Frontiers in Medicine Inflammatory Bowel Disease (IBD) inflammatory biomarkers endoscopy inflammation disease activity |
| author_facet |
Arno R. Bourgonje Julius Z. H. von Martels Ruben Y. Gabriëls Tjasso Blokzijl Manon Buist-Homan Janette Heegsma Bernadien H. Jansen Hendrik M. van Dullemen Eleonora A. M. Festen Rinze W. F. ter Steege Marijn C. Visschedijk Rinse K. Weersma Paul de Vos Klaas Nico Faber Klaas Nico Faber Gerard Dijkstra |
| author_sort |
Arno R. Bourgonje |
| title |
A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease |
| title_short |
A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease |
| title_full |
A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease |
| title_fullStr |
A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease |
| title_full_unstemmed |
A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease |
| title_sort |
combined set of four serum inflammatory biomarkers reliably predicts endoscopic disease activity in inflammatory bowel disease |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Medicine |
| issn |
2296-858X |
| publishDate |
2019-11-01 |
| description |
Introduction: Blood C-reactive protein (CRP) and fecal calprotectin levels are routinely measured as surrogate markers of disease activity in Inflammatory Bowel Disease (IBD), but often do not correlate well with the degree of mucosal inflammation in the intestine as established by endoscopy. Therefore, novel predictive biomarkers are urgently needed that better reflect mucosal disease activity in IBD. The aim of this study was to identify a combination of serum inflammatory biomarkers predictive for endoscopic disease activity.Methods: Serum concentrations of 10 inflammatory biomarkers were analyzed in 118 IBD patients [64 Crohn's disease (CD), 54 ulcerative colitis (UC)] and 20 healthy controls. In a subset of 71 IBD patients, endoscopic disease activity was established. Non-parametric ROC estimation with bootstrap inference was used to establish the best combination of inflammatory biomarkers predicting endoscopic disease activity.Results: Six (6) inflammatory biomarkers (serum amyloid A (SAA), Eotaxin-1, IL-6, IL-8, IL-17A, and TNF-α) showed better prediction of IBD disease activity than routine measures (CRP, fecal calprotectin and HBI/SCCAI scores). The best combination of predictive inflammatory biomarkers consisted of serum SAA, IL-6, IL-8, and Eotaxin-1, showing an optimism-adjusted area under the ROC (AuROC) curve of 0.84 (95% CI: 0.73–0.94, P < 0.0001), which predicted significantly better (P = 0.002) than serum CRP levels with an AuROC of 0.57 (95% CI: 0.43–0.72, P = 0.32).Conclusion: The combination of SAA, IL-6, IL-8, and Eotaxin-1 reliably predicts endoscopic disease activity in IBD and might be valuable for monitoring disease activity and management of the disease. |
| topic |
Inflammatory Bowel Disease (IBD) inflammatory biomarkers endoscopy inflammation disease activity |
| url |
https://www.frontiersin.org/article/10.3389/fmed.2019.00251/full |
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doaj-1d1cd076e6874f9da502d2e2b1e1d7252020-11-25T02:15:38ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2019-11-01610.3389/fmed.2019.00251486322A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel DiseaseArno R. Bourgonje0Julius Z. H. von Martels1Ruben Y. Gabriëls2Tjasso Blokzijl3Manon Buist-Homan4Janette Heegsma5Bernadien H. Jansen6Hendrik M. van Dullemen7Eleonora A. M. Festen8Rinze W. F. ter Steege9Marijn C. Visschedijk10Rinse K. Weersma11Paul de Vos12Klaas Nico Faber13Klaas Nico Faber14Gerard Dijkstra15Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Gastroenterology and Hepatology, Martini Hospital, Groningen, NetherlandsDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsIntroduction: Blood C-reactive protein (CRP) and fecal calprotectin levels are routinely measured as surrogate markers of disease activity in Inflammatory Bowel Disease (IBD), but often do not correlate well with the degree of mucosal inflammation in the intestine as established by endoscopy. Therefore, novel predictive biomarkers are urgently needed that better reflect mucosal disease activity in IBD. The aim of this study was to identify a combination of serum inflammatory biomarkers predictive for endoscopic disease activity.Methods: Serum concentrations of 10 inflammatory biomarkers were analyzed in 118 IBD patients [64 Crohn's disease (CD), 54 ulcerative colitis (UC)] and 20 healthy controls. In a subset of 71 IBD patients, endoscopic disease activity was established. Non-parametric ROC estimation with bootstrap inference was used to establish the best combination of inflammatory biomarkers predicting endoscopic disease activity.Results: Six (6) inflammatory biomarkers (serum amyloid A (SAA), Eotaxin-1, IL-6, IL-8, IL-17A, and TNF-α) showed better prediction of IBD disease activity than routine measures (CRP, fecal calprotectin and HBI/SCCAI scores). The best combination of predictive inflammatory biomarkers consisted of serum SAA, IL-6, IL-8, and Eotaxin-1, showing an optimism-adjusted area under the ROC (AuROC) curve of 0.84 (95% CI: 0.73–0.94, P < 0.0001), which predicted significantly better (P = 0.002) than serum CRP levels with an AuROC of 0.57 (95% CI: 0.43–0.72, P = 0.32).Conclusion: The combination of SAA, IL-6, IL-8, and Eotaxin-1 reliably predicts endoscopic disease activity in IBD and might be valuable for monitoring disease activity and management of the disease.https://www.frontiersin.org/article/10.3389/fmed.2019.00251/fullInflammatory Bowel Disease (IBD)inflammatory biomarkersendoscopyinflammationdisease activity |