Synapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway

Synapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway

Abstract Background The neuromuscular junction (NMJ) is a peripheral synapse critical to muscle contraction. Like acetylcholine receptors (AChRs), many essential proteins of NMJ are extremely concentrated at the postjunctional membrane. However, the mechanisms of synapse-specific concentration are n...

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Bibliographic Details
Main Authors: Hongyang Jing, Peng Chen, Tiankun Hui, Zheng Yu, Jin Zhou, Erkang Fei, Shunqi Wang, Dongyan Ren, Xinsheng Lai, Baoming Li
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Cell & Bioscience
Subjects:
Lrp4
Neuromuscular junction
β-gal
Muscle activity
Wnt non-canonical signaling
Online Access:https://doi.org/10.1186/s13578-021-00619-z

Internet

https://doi.org/10.1186/s13578-021-00619-z

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