Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment

Sirtuin enzymes depend on NAD+ to catalyze protein deacetylation. Therefore, the lowering of NAD+ during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals and humans. In this study, we used a genetic screen to identify two mutations in the catalytic dom...

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Bibliographic Details
Main Authors: Caitlin R. Ondracek, Vincent Frappier, Alison E. Ringel, Cynthia Wolberger, Leonard Guarente
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
Sir2
SIRT1
NAD+
aging
adaptive mutations
predictive protein modeling
kinetic analyses
yeast replicative lifespan
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302127

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http://www.sciencedirect.com/science/article/pii/S2211124717302127

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