Schwann Cell Autocrine and Paracrine Regulatory Mechanisms, Mediated by Allopregnanolone and BDNF, Modulate PKCε in Peripheral Sensory Neurons

Schwann Cell Autocrine and Paracrine Regulatory Mechanisms, Mediated by Allopregnanolone and BDNF, Modulate PKCε in Peripheral Sensory Neurons

Protein kinase type C-ε (PKCε) plays important roles in the sensitization of primary afferent nociceptors, such as ion channel phosphorylation, that in turn promotes mechanical hyperalgesia and pain chronification. In these neurons, PKCε is modulated through the local release of mediators by the sur...

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Bibliographic Details
Main Authors: Veronica Bonalume, Lucia Caffino, Luca F. Castelnovo, Alessandro Faroni, Flavio Giavarini, Sheng Liu, Donatella Caruso, Martin Schmelz, Fabio Fumagalli, Richard W. Carr, Valerio Magnaghi
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
neuro-glia interaction
neuropathic pain
hyperalgesia
dorsal root ganglia
neuroactive steroid
Online Access:https://www.mdpi.com/2073-4409/9/8/1874

Internet

https://www.mdpi.com/2073-4409/9/8/1874

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