A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A

The Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) is a component of commercial vaccines, but is unstable. Here, the authors generate glycomimetic oligomers that demonstrate higher stability than their natural counterparts and induce protective antibodies in mice.

Bibliographic Details
Main Authors: Jacopo Enotarpi, Marta Tontini, Cristiana Balocchi, Daan van der Es, Ludovic Auberger, Evita Balducci, Filippo Carboni, Daniela Proietti, Daniele Casini, Dmitri V. Filippov, Hermen S. Overkleeft, Gijsbert A. van der Marel, Cinzia Colombo, Maria Rosaria Romano, Francesco Berti, Paolo Costantino, Jeroen D. C. Codeé, Luigi Lay, Roberto Adamo
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18279-x

Internet

https://doi.org/10.1038/s41467-020-18279-x

Similar Items