Propofol Inhibits Cerebellar Parallel Fiber-Purkinje Cell Synaptic Transmission via Activation of Presynaptic GABAB Receptors in vitro in Mice

Propofol Inhibits Cerebellar Parallel Fiber-Purkinje Cell Synaptic Transmission via Activation of Presynaptic GABAB Receptors in vitro in Mice

Propofol is a widely used intravenous sedative-hypnotic agent, which causes rapid and reliable loss of consciousness via activation of γ -aminobutyric acid A (GABAA) receptors. We previously found that propofol inhibited cerebellar Purkinje cells (PC) activity via both GABAA and glycine receptors in...

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Bibliographic Details
Main Authors: Fang-Ling Xuan, Hong-Wei Wang, Li-Xin Cao, Yan-Hua Bing, Chun-Ping Chu, Ri Jin, De-Lai Qiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neuroscience
Subjects:
propofol
cerebellar Purkinje cell
whole-cell patch-clamp recording
GABAB receptor
parallel fiber
protein kinase A
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00922/full

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https://www.frontiersin.org/article/10.3389/fnins.2018.00922/full

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