bba, a synthetic derivative of 23-hydroxybutulinic acid, reverses multidrug resistance by inhibiting the efflux activity of MRP7 (ABCC10).

bba, a synthetic derivative of 23-hydroxybutulinic acid, reverses multidrug resistance by inhibiting the efflux activity of MRP7 (ABCC10).

Natural products are frequently used for adjuvant chemotherapy in cancer treatment. 23-O-(1,4'-bipiperidine-1-carbonyl) betulinic acid (BBA) is a synthetic derivative of 23-hydroxybutulinic acid (23-HBA), which is a natural pentacyclic triterpene and the major active constituent of the root of...

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Bibliographic Details
Main Authors: Jun-Jiang Chen, Atish Patel, Kamlesh Sodani, Zhi-Jie Xiao, Amit K Tiwari, Dong-Mei Zhang, Ying-Jie Li, Dong-Hua Yang, Wen-Cai Ye, Si-Dong Chen, Zhe-Sheng Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3775757?pdf=render

Internet

http://europepmc.org/articles/PMC3775757?pdf=render

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