Neuroprotective effects of human bone marrow mesenchymal stem cells against cerebral ischemia are mediated in part by an anti-apoptotic mechanism

Neuroprotective effects of human bone marrow mesenchymal stem cells against cerebral ischemia are mediated in part by an anti-apoptotic mechanism

Transplantation of human bone marrow mesenchymal stem cells (hMSCs) stands as a potent stroke therapy, but its exact mechanism remains unknown. This study investigated the anti-apoptotic mechanisms by which hMSCs exert neuroprotective effects on cerebral ischemia. Primary mixed cultures of rat neuro...

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Bibliographic Details
Main Authors: Yuyang Zhang, Seongjin Yu, Julian P Tuazon, Jea-Young Lee, Sydney Corey, Lauren Kvederis, Chase Kingsbury, Yuji Kaneko, Cesar V Borlongan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
apoptosis; Bcl-2 antibody; human mesenchymal stem cells; ischemia; neuroprotection; oxygen glucose deprivation
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=597;epage=604;aulast=Zhang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=597;epage=604;aulast=Zhang

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