Altered calcium homeostasis in motor neurons following AMPA receptor but not voltage-dependent calcium channels’ activation in a genetic model of amyotrophic lateral sclerosis

Altered calcium homeostasis in motor neurons following AMPA receptor but not voltage-dependent calcium channels’ activation in a genetic model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disease characterized by a substantial loss of motor neurons in the spinal cord, brain stem and motor cortex. By combining electrophysiological recordings with imaging techniques, clearance/buffering capacity of cultur...

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Bibliographic Details
Main Authors: Ezia Guatteo, Irene Carunchio, Massimo Pieri, Federica Albo, Nadia Canu, Nicola B. Mercuri, Cristina Zona
Format: Article
Language:English
Published: Elsevier 2007-10-01
Series:Neurobiology of Disease
Subjects:
Calcium homeostasis
Cell death
Motor neuron
fura2
Glutamate receptor
SOD1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107001386

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http://www.sciencedirect.com/science/article/pii/S0969996107001386

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