The Aza-Analogous Benzo[<i>c</i>]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties

The Aza-Analogous Benzo[<i>c</i>]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties

The benzo[<i>c</i>]phenanthridine P8-D6 was recently found to suppress the catalytic activity of both human topoisomerase (Topo) I and II. Concomitantly, potent cytotoxic activity was observed in different human tumor cell lines, raising questions about the underlying mechanisms in vitro...

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Bibliographic Details
Main Authors: Georg Aichinger, Falk-Bach Lichtenberger, Tamara N. Steinhauer, Inken Flörkemeier, Giorgia Del Favero, Bernd Clement, Doris Marko
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
chemotherapy
drug development
topoisomerase poisoning
dual topoisomerase inhibitor
genotoxicity
nuclear localization
Online Access:https://www.mdpi.com/1420-3049/25/7/1524

Internet

https://www.mdpi.com/1420-3049/25/7/1524

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