MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis

MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis

MEF2C is a transcription factor required for B-cell proliferation. Here the authors show that MEF2C is also needed in B-cell development and recovery from stress by inducing expression of DNA repair factors that prevent double stranded breaks and enable VDJ recombination.

Bibliographic Details
Main Authors: Wenyuan Wang, Tonis Org, Amélie Montel-Hagen, Peter D. Pioli, Dan Duan, Edo Israely, Daniel Malkin, Trent Su, Johanna Flach, Siavash K. Kurdistani, Robert H. Schiestl, Hanna K. A. Mikkola
Format: Article
Language:English
Published: Nature Publishing Group 2016-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12376

Internet

https://doi.org/10.1038/ncomms12376

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