The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes

The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes

Glutathione (GSH) is one of the most abundant thiol antioxidants in cells. Many chronic and age-related diseases are associated with a decline in cellular GSH levels or impairment in the catalytic activity of the GSH biosynthetic enzyme glutamate cysteine ligase (GCL). γ-glutamylcysteine (GGC), a pr...

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Bibliographic Details
Main Authors: Nady Braidy, Martin Zarka, Bat-Erdene Jugder, Jeffrey Welch, Tharusha Jayasena, Daniel K. Y. Chan, Perminder Sachdev, Wallace Bridge
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
glutathione
oxidative stress
antioxidants
dementia
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00177/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00177/full

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