Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase—Pol ε Interaction

Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase—Pol ε Interaction

The CMG complex (Cdc45, Mcm2–7, GINS (Psf1, 2, 3, and Sld5)) is crucial for both DNA replication initiation and fork progression. The CMG helicase interaction with the leading strand DNA polymerase epsilon (Pol ε) is essential for the preferential loading of Pol ε onto the leading strand, the stimul...

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Bibliographic Details
Main Authors: Milena Denkiewicz-Kruk, Malgorzata Jedrychowska, Shizuko Endo, Hiroyuki Araki, Piotr Jonczyk, Michal Dmowski, Iwona J. Fijalkowska
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
CMGE helicase-polymerase complex
GINS complex
<i>PSF1</i>/<i>GINS1</i>
DNA polymerase epsilon
Pol ε
polymerase zeta
Online Access:https://www.mdpi.com/1422-0067/21/24/9484

Internet

https://www.mdpi.com/1422-0067/21/24/9484

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