Single-Fluorescent Protein Reporters Allow Parallel Quantification of Natural Killer Cell-Mediated Granzyme and Caspase Activities in Single Target Cells

Single-Fluorescent Protein Reporters Allow Parallel Quantification of Natural Killer Cell-Mediated Granzyme and Caspase Activities in Single Target Cells

Natural killer (NK) cells eliminate infected and tumorigenic cells through delivery of granzymes via perforin pores or by activation of caspases via death receptors. In order to understand how NK cells combine different cell death mechanisms, it is important to quantify target cell responses on a si...

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Bibliographic Details
Main Authors: Clarissa Liesche, Patricia Sauer, Isabel Prager, Doris Urlaub, Maren Claus, Roland Eils, Joël Beaudouin, Carsten Watzl
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
cytotoxic lymphocytes
single-fluorescent protein reporters
granzyme and caspase activity
apoptosis and cell death
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01840/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01840/full

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