Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

Direct activation of the human phospholipase C-γ isozymes (PLC-γ1, -γ2) by tyrosine phosphorylation is fundamental to the control of diverse biological processes, including chemotaxis, platelet aggregation, and adaptive immunity. In turn, aberrant activation of PLC-γ1 and PLC-γ2 is implicated in inf...

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Bibliographic Details
Main Authors: Nicole Hajicek, Nicholas C Keith, Edhriz Siraliev-Perez, Brenda RS Temple, Weigang Huang, Qisheng Zhang, T Kendall Harden, John Sondek
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
phospholipase C
allostery
interfacial regulation
X-ray crystallography
molecular dynamics
cancer
Online Access:https://elifesciences.org/articles/51700

Internet

https://elifesciences.org/articles/51700

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