A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage

A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage

A full understanding of the molecular mechanisms implicated in the etiopathogenesis of juvenile idiopathic arthritis (JIA) is lacking. A critical role for leukocyte proteolytic activity (e.g., elastase and cathepsin G) has been proposed. While leukocyte elastase’s (HLE) role has been documented, the...

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Bibliographic Details
Main Authors: Eric K. Patterson, Nicolas Vanin Moreno, Douglas D. Fraser, Gediminas Cepinskas, Takaya Iida, Roberta A. Berard
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pathophysiology
Subjects:
proteinase 3
juvenile idiopathic arthritis
inflammation
synovial fluid
leukocyte elastase
myeloperoxidase
Online Access:https://www.mdpi.com/1873-149X/28/3/21

Internet

https://www.mdpi.com/1873-149X/28/3/21

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