Edaravone Enhances Brain-Derived Neurotrophic Factor Production in the Ischemic Mouse Brain

Edaravone Enhances Brain-Derived Neurotrophic Factor Production in the Ischemic Mouse Brain

Edaravone, a clinical drug used to treat strokes, protects against neuronal cell death and memory loss in the ischemic brains of animal models through its antioxidant activity. In the present study, we subcutaneously administrated edaravone to mice (3 mg/kg/day) for three days immediately after bil...

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Bibliographic Details
Main Authors: Satoshi Okuyama, Mayu Morita, Atsushi Sawamoto, Tsukasa Terugo, Mitsunari Nakajima, Yoshiko Furukawa
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Pharmaceuticals
Subjects:
edaravone
global cerebral ischemia
hippocampus
BDNF
neurogenesis
CaMK II
Online Access:http://www.mdpi.com/1424-8247/8/2/176

Internet

http://www.mdpi.com/1424-8247/8/2/176

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