Encouraging Clinical Evolution of a Pediatric Patient With Relapsed Diffuse Midline Glioma Who Underwent WT1-Targeting Immunotherapy: A Case Report and Literature Review

Encouraging Clinical Evolution of a Pediatric Patient With Relapsed Diffuse Midline Glioma Who Underwent WT1-Targeting Immunotherapy: A Case Report and Literature Review

Diffuse midline glioma (DMG) in children is a highly aggressive, malignant brain tumor that is fatal when relapsed. Wilms tumor 1 (WT1) is a high-priority antigen target for cancer immunotherapy. We hereby report on a pediatric patient who had DMG that regrew after chemoradiotherapy and underwent WT...

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Bibliographic Details
Main Authors: Yoshiko Hashii, Yoshihiro Oka, Naoki Kagawa, Naoya Hashimoto, Hiroyuki Saitou, Syogo Fukuya, Mizuki Kanegae, Sayaka Ikejima, Yusuke Oji, Keiichi Ozono, Akihiro Tsuboi, Haruo Sugiyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
WT1 peptide vaccine
immunotherapy
diffuse midline glioma
relapse
WT1-specific cytotoxic T cells
tetramer assay
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01188/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01188/full

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