Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice

Baseline iron status and presence of anaemia determine the course of systemic Salmonella infection following oral iron supplementation in mice

Background: Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. Methods: We fed male C57BL/6N mice with either an iron deficient or a...

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Bibliographic Details
Main Authors: Alexander Hoffmann, David Haschka, Lara Valente de Souza, Piotr Tymoszuk, Markus Seifert, Laura von Raffay, Richard Hilbe, Verena Petzer, Patrizia L Moser, Manfred Nairz, Günter Weiss
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:EBioMedicine
Subjects:
Iron deficiency anaemia
Salmonella infection
Iron supplementation
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421003613

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http://www.sciencedirect.com/science/article/pii/S2352396421003613

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