Predicting associations among drugs, targets and diseases by tensor decomposition for drug repositioning

Abstract Background Development of new drugs is a time-consuming and costly process, and the cost is still increasing in recent years. However, the number of drugs approved by FDA every year per dollar spent on development is declining. Drug repositioning, which aims to find new use of existing drug...

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Bibliographic Details
Main Authors: Ran Wang, Shuai Li, Lixin Cheng, Man Hon Wong, Kwong Sak Leung
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-019-3283-6