Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin
Placental malaria is caused by Plasmodium falciparum–infected erythrocytes that bind to placental tissue. Binding is mediated by VAR2CSA, a parasite antigen coded by the var gene, which interacts with chondroitin sulfate A (CSA). Consequences include maternal anemia and fetal growth retardation. Ant...
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doaj-1d71900f148d4759aa742be7cc7bd85b2020-11-24T21:50:37ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-05-0121581382310.3201/eid2105.141626Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, BeninNicaise Tuikue NdamLise Denoeud-NdamJustin DoritchamouFirmine ViwamiAli SalantiMorten A. NielsenNadine FievetAchille MassougbodjiAdrian J.F. LutyPhilippe DeloronPlacental malaria is caused by Plasmodium falciparum–infected erythrocytes that bind to placental tissue. Binding is mediated by VAR2CSA, a parasite antigen coded by the var gene, which interacts with chondroitin sulfate A (CSA). Consequences include maternal anemia and fetal growth retardation. Antibody-mediated immunity to placental malaria is acquired during successive pregnancies, but the target of VAR2CSA-specific protective antibodies is unclear. We assessed VAR2CSA-specific antibodies in pregnant women and analyzed their relationships with protection against placental infection, preterm birth, and low birthweight. Antibody responses to the N-terminal region of VAR2CSA during early pregnancy were associated with reduced risks for infections and low birthweight. Among women infected during pregnancy, an increase in CSA binding inhibition was associated with reduced risks for placental infection, preterm birth, and low birthweight. These data suggest that antibodies against VAR2CSA N-terminal region mediate immunity to placental malaria and associated outcomes. Our results validate current vaccine development efforts with VAR2CSA N-terminal constructs.https://wwwnc.cdc.gov/eid/article/21/5/14-1626_articlePlasmodium falciparumparasitesmalariaplacental malariavariant surface antigen 2 chondroitin sulfateVAR2CSA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicaise Tuikue Ndam Lise Denoeud-Ndam Justin Doritchamou Firmine Viwami Ali Salanti Morten A. Nielsen Nadine Fievet Achille Massougbodji Adrian J.F. Luty Philippe Deloron |
spellingShingle |
Nicaise Tuikue Ndam Lise Denoeud-Ndam Justin Doritchamou Firmine Viwami Ali Salanti Morten A. Nielsen Nadine Fievet Achille Massougbodji Adrian J.F. Luty Philippe Deloron Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin Emerging Infectious Diseases Plasmodium falciparum parasites malaria placental malaria variant surface antigen 2 chondroitin sulfate VAR2CSA |
author_facet |
Nicaise Tuikue Ndam Lise Denoeud-Ndam Justin Doritchamou Firmine Viwami Ali Salanti Morten A. Nielsen Nadine Fievet Achille Massougbodji Adrian J.F. Luty Philippe Deloron |
author_sort |
Nicaise Tuikue Ndam |
title |
Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin |
title_short |
Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin |
title_full |
Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin |
title_fullStr |
Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin |
title_full_unstemmed |
Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin |
title_sort |
protective antibodies against placental malaria and poor outcomes during pregnancy, benin |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2015-05-01 |
description |
Placental malaria is caused by Plasmodium falciparum–infected erythrocytes that bind to placental tissue. Binding is mediated by VAR2CSA, a parasite antigen coded by the var gene, which interacts with chondroitin sulfate A (CSA). Consequences include maternal anemia and fetal growth retardation. Antibody-mediated immunity to placental malaria is acquired during successive pregnancies, but the target of VAR2CSA-specific protective antibodies is unclear. We assessed VAR2CSA-specific antibodies in pregnant women and analyzed their relationships with protection against placental infection, preterm birth, and low birthweight. Antibody responses to the N-terminal region of VAR2CSA during early pregnancy were associated with reduced risks for infections and low birthweight. Among women infected during pregnancy, an increase in CSA binding inhibition was associated with reduced risks for placental infection, preterm birth, and low birthweight. These data suggest that antibodies against VAR2CSA N-terminal region mediate immunity to placental malaria and associated outcomes. Our results validate current vaccine development efforts with VAR2CSA N-terminal constructs. |
topic |
Plasmodium falciparum parasites malaria placental malaria variant surface antigen 2 chondroitin sulfate VAR2CSA |
url |
https://wwwnc.cdc.gov/eid/article/21/5/14-1626_article |
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