Performance of genotype imputation for rare variants identified in exons and flanking regions of genes.

Performance of genotype imputation for rare variants identified in exons and flanking regions of genes.

Genotype imputation has the potential to assess human genetic variation at a lower cost than assaying the variants using laboratory techniques. The performance of imputation for rare variants has not been comprehensively studied. We utilized 8865 human samples with high depth resequencing data for t...

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Bibliographic Details
Main Authors: Li Li, Yun Li, Sharon R Browning, Brian L Browning, Andrew J Slater, Xiangyang Kong, Jennifer L Aponte, Vincent E Mooser, Stephanie L Chissoe, John C Whittaker, Matthew R Nelson, Margaret Gelder Ehm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3176314?pdf=render

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http://europepmc.org/articles/PMC3176314?pdf=render

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