Role of monoubiquitylation on the control of IκBα degradation and NF-κB activity.

Role of monoubiquitylation on the control of IκBα degradation and NF-κB activity.

The NF-κB pathway is regulated by multiple post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. Many of these modifications act on the natural inhibitor IκBα modulating its capacity to control signal-mediated NF-κB activity. While the canonical pathway involvin...

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Bibliographic Details
Main Authors: Elisa Da Silva-Ferrada, Mónica Torres-Ramos, Fabienne Aillet, Michela Campagna, Carlos Matute, Carmen Rivas, Manuel S Rodríguez, Valérie Lang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3192046?pdf=render

Internet

http://europepmc.org/articles/PMC3192046?pdf=render

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