HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon

HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon

Summary: Here, we report our studies of immune-mediated regulation of Zika virus (ZIKV), herpes simplex virus 1 (HSV-1), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the human cornea. We find that ZIKV can be transmitted via corneal transplantation in mice. However,...

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Bibliographic Details
Main Authors: Jonathan J. Miner, Derek J. Platt, Cyrus M. Ghaznavi, Pallavi Chandra, Andrea Santeford, Amber M. Menos, Zhenyu Dong, Erin R. Wang, Wei Qian, Elysse S. Karozichian, Jennifer A. Philips, Rajendra S. Apte
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
SARS-CoV-2
coronavirus
herpes simplex virus
Zika virus
eye
cornea
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720313280

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http://www.sciencedirect.com/science/article/pii/S2211124720313280

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