Basal Activation of Type I Interferons (Alpha2 and Beta) and 2′5′OAS Genes: Insights into Differential Expression Profiles of Interferon System Components in Systemic Sclerosis

Basal Activation of Type I Interferons (Alpha2 and Beta) and 2′5′OAS Genes: Insights into Differential Expression Profiles of Interferon System Components in Systemic Sclerosis

Objective. Systemic sclerosis (SSc) is a complex autoimmune disease in which interferons (IFNs) may play an essential role. We hypothesized that type I and III IFNs may be found in increased levels in patients and be responsible for SSc autoimmune status. Methods. Type I and III IFN and ISG basal ex...

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Bibliographic Details
Main Authors: Danilo Bretas de Oliveira, Gabriel Magno de Freitas Almeida, Antônio Carlos Martins Guedes, Flávia Patrícia Sena Teixeira Santos, Claudio Antônio Bonjardim, Paulo César Peregrino Ferreira, Erna Geessien Kroon
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:International Journal of Rheumatology
Online Access:http://dx.doi.org/10.1155/2011/275617

Internet

http://dx.doi.org/10.1155/2011/275617

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