Protein coding mitochondrial-targeted RNAs rescue mitochondrial disease in vivo

Protein coding mitochondrial-targeted RNAs rescue mitochondrial disease in vivo

Mitochondrial encephalomyopathies (MEs) result from mutations in mitochondrial genes critical to oxidative phosphorylation. Severe and untreatable ME results from mutations affecting each endogenous mitochondrial encoded gene, including all 13 established protein coding genes. Effective techniques t...

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Bibliographic Details
Main Authors: Desiree M. Markantone, Atif Towheed, Aaron T. Crain, Jessica M. Collins, Alicia M. Celotto, Michael J. Palladino
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Neurobiology of Disease
Subjects:
Allotopic RNA expression
Mitochondrial RNA import
Drosophila
Mitochondrial encephalomyopathy (ME)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301864

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http://www.sciencedirect.com/science/article/pii/S0969996118301864

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