Impaired regeneration in calpain-3 null muscle is associated with perturbations in mTORC1 signaling and defective mitochondrial biogenesis

Impaired regeneration in calpain-3 null muscle is associated with perturbations in mTORC1 signaling and defective mitochondrial biogenesis

Abstract Background Previous studies in patients with limb-girdle muscular dystrophy type 2A (LGMD2A) have suggested that calpain-3 (CAPN3) mutations result in aberrant regeneration in muscle. Methods To gain insight into pathogenesis of aberrant muscle regeneration in LGMD2A, we used a paradigm of...

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Bibliographic Details
Main Authors: Mehmet E. Yalvac, Jakkrit Amornvit, Cilwyn Braganza, Lei Chen, Syed-Rehan A. Hussain, Kimberly M. Shontz, Chrystal L. Montgomery, Kevin M. Flanigan, Sarah Lewis, Zarife Sahenk
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Skeletal Muscle
Subjects:
LGMD2A
Skeletal muscle regeneration
Impaired radial growth
mTORC1
Mitochondrial biogenesis
Online Access:http://link.springer.com/article/10.1186/s13395-017-0146-6

Internet

http://link.springer.com/article/10.1186/s13395-017-0146-6

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