Metformin Protects against Radiation-Induced Acute Effects by Limiting Senescence of Bronchial-Epithelial Cells

Metformin Protects against Radiation-Induced Acute Effects by Limiting Senescence of Bronchial-Epithelial Cells

Radiation-induced damage to normal lung parenchyma remains a dose-limiting factor in thorax-associated radiotherapy (RT). Severe early and late complications with lungs can increase the risk of morbidity in cancer patients after RT. Herein, senescence of lung epithelial cells following RT-induced ce...

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Bibliographic Details
Main Authors: Christine Hansel, Samantha Barr, Alina V. Schemann, Kirsten Lauber, Julia Hess, Kristian Unger, Horst Zitzelsberger, Verena Jendrossek, Diana Klein
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
radiotherapy
normal tissue toxicity
lung injury
pulmonary disease
premature senescence
senescence-associated secretory phenotype
Online Access:https://www.mdpi.com/1422-0067/22/13/7064

Internet

https://www.mdpi.com/1422-0067/22/13/7064

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