The PtdIns 3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphoma.

The PtdIns 3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphoma.

Macrophages are important effectors in the clearance of antibody-coated tumor cells. However, the signaling pathways that regulate macrophage-induced ADCC are poorly defined. To understand the regulation of macrophage-mediated ADCC, we used human B cell lymphoma coated with Rituximab as the tumor ta...

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Bibliographic Details
Main Authors: Trupti Joshi, Latha P Ganesan, Carolyn Cheney, Michael C Ostrowski, Natarajan Muthusamy, John C Byrd, Susheela Tridandapani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2615217?pdf=render

Internet

http://europepmc.org/articles/PMC2615217?pdf=render

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