Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice

Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice

Inherited defects in purine nucleoside phosphorylase (PNP) cause severe T cell immunodeficiency and progressive neurological dysfunction, yet little is known about the effects of PNP deficiency on the brain. PNP-KO mice display metabolic and immune anomalies similar to those observed in patients. Ou...

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Bibliographic Details
Main Authors: Alireza Mansouri, Weixian Min, Christina J. Cole, Sheena A. Josselyn, Jeffrey Theodore Henderson, Matthijs van Eede, R. Mark Henkelman, Cameron Ackerley, Eyal Grunebaum, Chaim M. Roifman
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Neurobiology of Disease
Subjects:
Cerebellum
Purine nucleoside phosphorylase
Purkinje cells
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112001301

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http://www.sciencedirect.com/science/article/pii/S0969996112001301

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