Comparative transcriptomics reveals PrrAB-mediated control of metabolic, respiration, energy-generating, and dormancy pathways in Mycobacterium smegmatis

Comparative transcriptomics reveals PrrAB-mediated control of metabolic, respiration, energy-generating, and dormancy pathways in Mycobacterium smegmatis

Abstract Background Mycobacterium smegmatis is a saprophytic bacterium frequently used as a genetic surrogate to study pathogenic Mycobacterium tuberculosis. The PrrAB two-component genetic regulatory system is essential in M. tuberculosis and represents an attractive therapeutic target. In this stu...

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Bibliographic Details
Main Authors: Jason D. Maarsingh, Shanshan Yang, Jin G. Park, Shelley E. Haydel
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Genomics
Subjects:
Mycobacterium smegmatis
Mycobacterium tuberculosis
prrAB
Two-component system
RNA-seq
Transcriptomics
Online Access:https://doi.org/10.1186/s12864-019-6105-3

Internet

https://doi.org/10.1186/s12864-019-6105-3

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