Synthesis of a Fluorous-Tagged Hexasaccharide and Interaction with Growth Factors Using Sugar-Coated Microplates

Synthesis of a Fluorous-Tagged Hexasaccharide and Interaction with Growth Factors Using Sugar-Coated Microplates

Here, we report the synthesis of a sulfated, fully protected hexasaccharide as a glycosaminoglycan mimetic and the study of its interactions with different growth factors: midkine, basic fibroblast growth factor (FGF-2) and nerve growth factor (NGF). Following a fluorous-assisted approach, monosacch...

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Bibliographic Details
Main Authors: Susana Maza, José L. de Paz, Pedro M. Nieto
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Molecules
Subjects:
oligosaccharide synthesis
fluorous tag
glycosaminoglycan mimetics
carbohydrate-protein interactions
Online Access:https://www.mdpi.com/1420-3049/24/8/1591

Internet

https://www.mdpi.com/1420-3049/24/8/1591

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