Recombinant Lactococcus Lactis Expressing M1-HA2 Fusion Protein Provides Protective Mucosal Immunity Against H9N2 Avian Influenza Virus in Chickens

Recombinant Lactococcus Lactis Expressing M1-HA2 Fusion Protein Provides Protective Mucosal Immunity Against H9N2 Avian Influenza Virus in Chickens

H9N2 subtype low pathogenicity avian influenza virus (LPAIV) is distributed worldwide and causes enormous economic losses in the poultry industry. Despite immunization of almost all chickens with inactivated vaccines, the disease still remains widespread. We speculated that improving mucosal or cell...

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Bibliographic Details
Main Authors: Zhou Sha, Hongqi Shang, Yongqiang Miao, Jin Huang, Xiangyun Niu, Ruichang Chen, Liping Hu, He Huang, Kai Wei, Ruiliang Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Veterinary Science
Subjects:
H9N2
immune responses
Lactococcus lactis
oral vaccine
mucosal immune
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2020.00153/full

Internet

https://www.frontiersin.org/article/10.3389/fvets.2020.00153/full

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