Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells

Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells

Loss of CD28 is a characteristic feature of T cell aging, but the underlying mechanisms of this loss are elusive. As differential expression of microRNAs (miRNAs) has been described between CD28+ and CD28− T cells, we hypothesized that altered miRNA expression contributes to the age-associated downr...

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Bibliographic Details
Main Authors: Nato Teteloshvili, Gerjan Dekkema, Annemieke M. Boots, Peter Heeringa, Pytrick Jellema, Debora de Jong, Martijn Terpstra, Elisabeth Brouwer, Graham Pawelec, Klaas Kok, Anke van den Berg, Joost Kluiver, Bart-Jan Kroesen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
T cell aging
senescence
CD28
IL-15
miRNA
miR-9
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01400/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01400/full

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