TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophila

TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophila

TDP-43 proteinopathy is strongly implicated in the pathogenesis of amyotrophic lateral sclerosis and related neurodegenerative disorders. Whether TDP-43 neurotoxicity is caused by a novel toxic gain-of-function mechanism of the aggregates or by a loss of its normal function is unknown. We increased...

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Bibliographic Details
Main Authors: Lies Vanden Broeck, Marina Naval-Sánchez, Yoshitsugu Adachi, Danielle Diaper, Pierre Dourlen, Julien Chapuis, Gernot Kleinberger, Marc Gistelinck, Christine Van Broeckhoven, Jean-Charles Lambert, Frank Hirth, Stein Aerts, Patrick Callaerts, Bart Dermaut
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712004597

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http://www.sciencedirect.com/science/article/pii/S2211124712004597

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