Decreased prevalence of the Plasmodium falciparum Pfcrt K76T and Pfmdr1 and N86Y mutations post-chloroquine treatment withdrawal in Katete District, Eastern Zambia

Decreased prevalence of the Plasmodium falciparum Pfcrt K76T and Pfmdr1 and N86Y mutations post-chloroquine treatment withdrawal in Katete District, Eastern Zambia

Abstract Background In 2002, Zambia withdrew chloroquine as first-line treatment for Plasmodium falciparum malaria due to increased treatment failure and worldwide spread of chloroquine resistance. The artemisinin combination regimen, artemether–lumefantrine, replaced chloroquine (CQ) as first choic...

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Bibliographic Details
Main Authors: Mwenda C. Mulenga, Lungowe Sitali, Ilinca I. Ciubotariu, Moonga B. Hawela, Busiku Hamainza, James Chipeta, Sungano Mharakurwa
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Malaria Journal
Subjects:
Chloroquine resistance
Chloroquine sensitivity
Malaria
Mutation
Genotypes
Online Access:https://doi.org/10.1186/s12936-021-03859-z

Internet

https://doi.org/10.1186/s12936-021-03859-z

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