Functional roles of Tryptophan residues in diketoreductase from Acinetobacter baylyi

Functional roles of Tryptophan residues in diketoreductase from Acinetobacter baylyi

Diketoreductase (DKR) from Acinetobacter baylyi contains twotryptophan residues at positions 149 and 222. Trp-149 andTrp-222 are located along the entry path of substrate into activesite and at the dimer interface of DKR, respectively. Single anddouble substitutions of these positions were generated...

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Bibliographic Details
Main Author: Yan Huang1, Zhuo Lu1, Min Ma1, Nan Liu1 & Yijun Chen1,2,*
Format: Article
Language:English
Published: Korean Society for Biochemistry and Molecular Biology 2012-08-01
Series:BMB Reports
Subjects:
Diketoreductase
Enzyme kinetics
Hydrophobic interaction
Site-directed mutagenesis
Tryptophan
Online Access:http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTIyMTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS04JTVEMTIwODMwMTcxOF8lMjg0NTItNDU3JTI5Qk1CXzEyLTA2NC5wZGY=

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http://www.jbmb.or.kr/jbmb/pdf.php?data=MTMwMTIyMTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0NS04JTVEMTIwODMwMTcxOF8lMjg0NTItNDU3JTI5Qk1CXzEyLTA2NC5wZGY=

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