Deep learning enables the atomic structure determination of the Fanconi Anemia core complex from cryoEM

Cryo-electron microscopy of protein complexes often leads to moderate resolution maps (4–8 Å), with visible secondary-structure elements but poorly resolved loops, making model building challenging. In the absence of high-resolution structures of homologues, only coarse-grained structural features a...

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Bibliographic Details
Main Authors: Daniel P. Farrell, Ivan Anishchenko, Shabih Shakeel, Anna Lauko, Lori A. Passmore, David Baker, Frank DiMaio
Format: Article
Language:English
Published: International Union of Crystallography 2020-09-01
Series:IUCrJ
Subjects:
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252520009306