Pharmacological Inhibition of Class IIA HDACs by LMK-235 in Pancreatic Neuroendocrine Tumor Cells

Pharmacological Inhibition of Class IIA HDACs by LMK-235 in Pancreatic Neuroendocrine Tumor Cells

Histone deacetylases (HDACs) play a key role in epigenetic mechanisms in health and disease and their dysfunction is implied in several cancer entities. Analysis of expression patterns in pancreatic neuroendocrine tumors (pNETs) indicated HDAC5 to be a potential target for future therapies. As a fir...

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Bibliographic Details
Main Authors: Julia Wanek, Martin Gaisberger, Marlena Beyreis, Christian Mayr, Katharina Helm, Florian Primavesi, Tarkan Jäger, Pietro Di Fazio, Martin Jakab, Andrej Wagner, Daniel Neureiter, Tobias Kiesslich
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic neuroendocrine tumors
histone deacetylases
LMK-235
cytotoxicity
apoptosis
Online Access:http://www.mdpi.com/1422-0067/19/10/3128

Internet

http://www.mdpi.com/1422-0067/19/10/3128

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